Oxidative/Nitrosative Stress and Protein Damages in Aqueous Humor of Hyperglycemic Rabbits: Effects of Two Oral Antidiabetics, Pioglitazone and Repaglinide

Athero-protective actions of two oral antidiabetic drugs: Suppression of inflammation and oxidative stress

Diabetes mellitus increases the risk and accelerates the clinical course of atherosclerosis, and is responsible for majority of the deaths and disabilities in type 2 diabetic population.[1] Optimal strategies to prevent the onset or progression of atherosclerosis will improve the clinical outcome of this high-risk population. In the current study, the research team showed that two antidiabetic ...

Effects of SLCO1B1 polymorphism on the pharmacokinetics of the oral antidiabetic drugs repaglinide, nateglinide, rosiglitazone, and pioglitazone

Synergism effects of pioglitazone and Urtica dioica extract in streptozotocin-induced nephropathy via attenuation of oxidative stress

Objective(s): Hyperglycemia promotes oxidative stress that plays a crucial role in the pathogenesis of Diabetic nephropathy (DN). In this study, we investigated the synergism effects of hydroalcoholic extract of Urtica dioica and pioglitazone (PIO) on the prevention of DN in streptozotocin induced-diabetic mice. Materials and Methods: Forty-two mice were divided into six groups as follows: non-...

P-49: Comparative Appraisal of Acarbose, Pioglitazone and Repaglinide on Histopathology of Testis in Streptozotocin Induced Diabetic Rats

Background: Experimentally induced diabetes in male rats is associated with alteration in functions of reproductive system. Acarbose, Pioglitazone and Repaglinide via decrease in blood glucose level can prevent the damage of testes. Materials and Methods: A total of 96 adult male albino rats whit a body weighing between 230- 250 g were injected by a single intraperitoneal injection of streptozo...

P-169: Protective Effect of Vitamin E on Cypermethrin - Induced Damages Correlates with P53 Gene Expression and Nitrosative Stress

Background: Because of fast rate of degradation and low mammalian cells toxicity the cypermethrin (CPM) is a wide used insecticide in domestic agriculture and in veterinary medicine applications. The compound exerts its pathological impact by down-regulating the antioxidant status. Therefore, current study was designed to evaluate the protective effect of vitamin E on CPMinduced apoptosis and n...